PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4096)
Related Products (4096)
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PROTAC Linkers Isoform Comparison
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19-Methoxy-19-oxononadecanoic acid
0 ImagesCat. No.: HY-W460257CAS No.: 72849-43-5
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16-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]hexadecanoic acid
![16-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]hexadecanoic acid](https://file.medchemexpress.com/product_pic/hy-w854304.gif "Click to View 16-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]hexadecanoic acid Product Detail")
0 ImagesCat. No.: HY-W854304CAS No.: 1356220-22-8
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Ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate
0 ImagesCat. No.: HY-W249951CAS No.: 1166829-72-6
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14-Mercaptotetradecanoic acid
0 ImagesCat. No.: HY-W092216CAS No.: 184639-68-7
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Acid-PEG4-NHS ester
0 ImagesCat. No.: HY-W800686CAS No.: 2639395-41-6Acid-PEG4-NHS ester is a PEG4-based PROTAC linker that can be used for the synthesis of PROTACs. Acid-PEG4-NHS ester contains a carboxylic acid and an NHS ester; the carboxylic acid reacts with primary amines in the presence of activators such as EDC or HATU, while the NHS ester also reacts with primary amines, enabling PEGylation and bioconjugation of primary amine-containing molecules.
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Boc-Piperidine-piperazine-Cbz
0 ImagesCat. No.: HY-W904851CAS No.: 177276-40-3
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Methyl 2-(3-(2-hydroxyethyl)bicyclo[1.1.1]pentan-1-yl)acetate
![Methyl 2-(3-(2-hydroxyethyl)bicyclo[1.1.1]pentan-1-yl)acetate](https://file.medchemexpress.com/product_pic/hy-w259813.gif "Click to View Methyl 2-(3-(2-hydroxyethyl)bicyclo[1.1.1]pentan-1-yl)acetate Product Detail")
0 ImagesCat. No.: HY-W259813CAS No.: 2168032-82-2
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tert-Butyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W006350CAS No.: 896103-62-1
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tert-Butyl (4-(piperazin-1-yl)butyl)carbamate
0 ImagesCat. No.: HY-W088455CAS No.: 874831-61-5
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Benzyl (2-(2-bromoethoxy)ethyl)carbamate
0 ImagesCat. No.: HY-W761208CAS No.: 2100292-22-4
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Hexane-1,6-diamine dihydrochloride
0 ImagesCat. No.: HY-W015248CAS No.: 6055-52-3
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N-Boc-15-aminopentadecanoic acid
0 ImagesCat. No.: HY-W591967CAS No.: 1661040-68-1N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. N-Boc-15-aminopentadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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3-Azetidinepropanenitrile, 2,2,2-trifluoroacetate (1:1)
0 ImagesCat. No.: HY-W394123CAS No.: 2624132-44-9
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N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5
0 ImagesCat. No.: HY-141038CAS No.: 2107273-80-1
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Methyl 4-[(piperazin-1-yl)methyl]benzoate
![Methyl 4-[(piperazin-1-yl)methyl]benzoate](https://file.medchemexpress.com/product_pic/hy-w179675.gif "Click to View Methyl 4-[(piperazin-1-yl)methyl]benzoate Product Detail")
0 ImagesCat. No.: HY-W179675CAS No.: 86620-81-7
